Dissociation of grey and white matter reduction in spinocerebellar ataxia type 3 and 6: a voxel-based morphometry study
C Lukas, L Schöls, B Bellenberg, U Rüb, H Przuntek… - Neuroscience …, 2006 - Elsevier
The aim of this study was to examine the different patterns of cerebellar and/or brainstem
atrophy in spinocerebellar ataxia (SCA) type 3 and 6. Eighteen patients (SCA3 n= 9, SCA6
n= 9) and 15 healthy volunteers were studied. Voxel-based morphometry (VBM) was
applied to segmented grey matter (GM) and white matter (WM) of high-resolution T1-
weighted brain volumes of each group. We found reduction of grey matter in the pons as
well as in the vermis in SCA3 as compared to control subjects. In SCA6 significant grey …
atrophy in spinocerebellar ataxia (SCA) type 3 and 6. Eighteen patients (SCA3 n= 9, SCA6
n= 9) and 15 healthy volunteers were studied. Voxel-based morphometry (VBM) was
applied to segmented grey matter (GM) and white matter (WM) of high-resolution T1-
weighted brain volumes of each group. We found reduction of grey matter in the pons as
well as in the vermis in SCA3 as compared to control subjects. In SCA6 significant grey …
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